Hyperpolarized Pyruvate MR Spectroscopy Depicts Glycolytic Inhibition in a Mouse Model of Glioma
نویسندگان
چکیده
منابع مشابه
Priority Report Evaluation of LDH-A and Glutaminase Inhibition In Vivo by Hyperpolarized C-Pyruvate Magnetic Resonance Spectroscopy of Tumors
Hyperpolarized C magnetic resonance spectroscopy provides a unique opportunity to detect real-time metabolic fluxes as ameans tomeasuremetabolic treatment responses in vivo. Here, we show that pharmacologic inhibition of lactate dehydrogenase-A suppressed the conversion of hyperpolarized C-pyruvate to lactate in murine xenografts of P493 human lymphoma. In contrast, a glutaminase inhibitor redu...
متن کاملEvaluation of LDH-A and Glutaminase Inhibition In Vivo by Hyperpolarized C-Pyruvate Magnetic Resonance Spectroscopy of Tumors
Hyperpolarized C magnetic resonance spectroscopy provides a unique opportunity to detect real-time metabolic fluxes as ameans tomeasuremetabolic treatment responses in vivo. Here, we show that pharmacologic inhibition of lactate dehydrogenase-A suppressed the conversion of hyperpolarized C-pyruvate to lactate in murine xenografts of P493 human lymphoma. In contrast, a glutaminase inhibitor redu...
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Hyperpolarized (13)C magnetic resonance spectroscopy provides a unique opportunity to detect real-time metabolic fluxes as a means to measure metabolic treatment responses in vivo. Here, we show that pharmacologic inhibition of lactate dehydrogenase-A suppressed the conversion of hyperpolarized (13)C-pyruvate to lactate in murine xenografts of P493 human lymphoma. In contrast, a glutaminase inh...
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treated tumor (center). The peak pyruvate signal has been scale to 1 and the origin of time (t=0) has been chosen to coincide with the peak of the pyruvate signal. The panel at right shows an axial proton image of the tumor (indicated by the green ellipse) and the location of the surface coil (indicated by the red line). The diagonal line at upper left is a water-filled fiducial marker. Monitor...
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ژورنال
عنوان ژورنال: Radiology
سال: 2019
ISSN: 0033-8419,1527-1315
DOI: 10.1148/radiol.2019182919